To All,
For what I call "practical hunting accuracy" with a 280 grain GCCB, 50 grains of Varget or 48 grains of IMR4895 seems quite adequate for most big game up to Elk/Bears/African Plains Game & in a majority of properly chambered rifles in good serviceable condition, out to 200M.
(You cannot kill an animal deader than GYD.)
just my opinion, tex