Well now, I have both the .44 Special and .45 Colt S&W guns. Both are accurate and reliable. .44 Special brass (in most brands) is thicker, so longer case life. Of course I'm kinda prejudiced. I have a .45 Colt, it is a 4", Mountain Gun (light, tapered barrel). The first time I tried it on the silhouette range, I pulled up, there was this young (20's) married couple there. I put 5 rounds in the cylinder. Load was a 230 grain Lee TC bevel-base boolit w/ 9 grains of Herco. I was on my hind legs and fired the first round @ the 220 yard rams. There was this faint "clank" sound, and the dang ram slowly fell over!
The youngsters, their jaws kinda dropped! Me, I just gave a faint smile! I changed real quick to the easy 100 yard plates, Ray Charles could bang them over.
Easy way to decide, get both & be happy.